Computationally guided organometallic chemistry: preparation of the heptacyclic pyrazine core of ritterazine N.

نویسندگان

  • Douglass F Taber
  • Karen V Taluskie
چکیده

Diels-Alder cycloaddition of 10 followed by Wittig homologation and intramolecular diene cyclozirconation of the resulting triene under equilibrating conditions led to the tricyclic 6-6-5 ketone 5 with high diastereocontrol. The derived alpha-azido ketone 16 cyclized efficiently to the heptacyclic pyrazine core of ritterazine N.

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عنوان ژورنال:
  • The Journal of organic chemistry

دوره 71 7  شماره 

صفحات  -

تاریخ انتشار 2006